Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425763 | 0.85 | GAA (0.52) | GAAMGAMSIMGAM2CYP1A2 | |
| SCHEMBL5012046 | 0.81 | ACHE (0.49) | ACHE | |
| SCHEMBL1784924 | 0.81 | CTSK (0.51) | GAAMGAMSIMGAM2CTSK | |
| SCHEMBL7452147 | 0.80 | HTT (0.39) | GAAACHEKMT2A | |
| SCHEMBL11479242 | 0.79 | GAA (0.45) | GAAMGAMSIMGAM2CYP1A2 | |
| SCHEMBL4660926 | 0.77 | GAA (0.47) | GAAMGAMSIMGAM2CTSK | |
| SCHEMBL13073328 | 0.77 | ACHE (0.66) | ACHE | |
| SCHEMBL15359356 | 0.76 | GAA (0.50) | GAAMGAMSIMGAM2CTSK | |
| SCHEMBL20188130 | 0.76 | TSHR (0.48) | GAAMGAMSIMGAM2ACHE | |
| SCHEMBL15728746 | 0.76 | CTSK (0.50) | GAACTSKCYP1A2KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124824-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026212-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2000-05-11 | — | — | WO | disclosed |