Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432370 | 0.89 | HPGD (0.48) | RAB9ANPC1HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL7438139 | 0.85 | P2RX7 (0.36) | — | |
| SCHEMBL7447168 | 0.77 | RAB9A (0.60) | RAB9ANPC1HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL7677990 | 0.77 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2POLBMAPTTHRB | |
| SCHEMBL7431049 | 0.77 | CYP1A2 (0.49) | RAB9ANPC1HPGDL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7447162 | 0.76 | RAB9A (0.59) | RAB9ANPC1HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL7438485 | 0.76 | CYP1A2 (0.44) | RAB9ANPC1HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL7443556 | 0.76 | CYP1A2 (0.47) | RAB9ANPC1HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL7433684 | 0.76 | CASP1 (0.40) | POLB | |
| SCHEMBL7427545 | 0.76 | RAB9A (0.52) | RAB9ANPC1HPGDL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |