Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2408044 | 0.93 | IDO1 (0.68) | IDO1MAOAMAOBLTA4HALDH1A1 | |
| SCHEMBL27463205 | 0.91 | IDO1 (0.65) | IDO1MAOAMAOBLTA4HALDH1A1 | |
| SCHEMBL7446482 | 0.88 | IDO1 (0.62) | IDO1MAOAMAOBLTA4HALDH1A1 | |
| SCHEMBL9294674 | 0.80 | ALDH1A1 (0.47) | IDO1MAOAMAOBLTA4HALDH1A1 | |
| SCHEMBL15929631 | 0.80 | ALDH1A1 (0.47) | IDO1MAOAMAOBLTA4HALDH1A1 | |
| SCHEMBL9242729 | 0.80 | MAOA (0.74) | MAOAMAOBLTA4HALDH1A1KDM4E | |
| SCHEMBL457634 | 0.80 | MAOA (0.74) | MAOAMAOBLTA4HALDH1A1KDM4E | |
| SCHEMBL636168 | 0.80 | ALDH1A1 (0.47) | IDO1MAOAMAOBLTA4HALDH1A1 | |
| SCHEMBL27435779 | 0.78 | MAOA (0.64) | IDO1MAOAMAOBLTA4HALDH1A1 | |
| SCHEMBL30385926 | 0.77 | MAOA (0.70) | MAOAMAOBLTA4HALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070069-A1 | BICYCLIC HYDROXAMIC ACID DERIVATIVES | Pfizer Products Inc. (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999052910-A1 | BICYCLIC HYDROXAMIC ACID DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1999-10-21 | — | — | WO | disclosed |