Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | HCN1 | O60741 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30848463 | 0.78 | HPGD (0.60) | P2RX7HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL397839 | 0.77 | HPGD (0.51) | P2RX7HPGDNPC1RAB9AL3MBTL1 | |
| SCHEMBL30848451 | 0.76 | HPGD (0.47) | P2RX7HPGDNPC1RAB9AL3MBTL1 | |
| SCHEMBL21652024 | 0.76 | P2RX7 (0.57) | P2RX7HPGDHCN1NPC1RAB9A | |
| SCHEMBL7278221 | 0.76 | CXCR5 (0.54) | P2RX7L3MBTL1 | |
| SCHEMBL13193074 | 0.73 | HPGD (0.47) | P2RX7HPGDHCN1NPC1RAB9A | |
| SCHEMBL10279699 | 0.73 | NPC1 (0.48) | P2RX7HPGDNPC1RAB9AL3MBTL1 | |
| SCHEMBL20068953 | 0.73 | P2RX7 (0.47) | P2RX7HPGDCCR8HCN1NPC1 | |
| SCHEMBL31079661 | 0.72 | HPGD (0.46) | P2RX7HPGDHCN1NPC1RAB9A | |
| SCHEMBL13164041 | 0.72 | PYGL (0.54) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491148-A | TREATING GASTROINTESTINAL, CARDIOVASCULAR, CENTRAL NERVOUS SYSTEM DISORDERS, EMESIS, PAIN | SYNTEX (U.S.A.) INC. (US) | 1996-02-13 | — | — | US | disclosed |