Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | CCKBR | P32239 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10460775 | 0.92 | ABCB11 (0.57) | HRH1PAX8MEN1ABCB11CHRM2 | |
| SCHEMBL7446850 | 0.91 | PAX8 (0.51) | HRH1PAX8MEN1ABCB11CHRM2 | |
| SCHEMBL7442321 | 0.91 | PAX8 (0.51) | HRH1PAX8MEN1ABCB11CHRM2 | |
| SCHEMBL7435992 | 0.90 | HRH1 (0.54) | HRH1PAX8ABCB11CHRM2HTR1A | |
| SCHEMBL7432581 | 0.88 | CYP2J2 (0.48) | HRH1PAX8MEN1ABCB11CHRM2 | |
| SCHEMBL7440209 | 0.85 | MEN1 (0.50) | HRH1PAX8MEN1HTR1ADRD2 | |
| SCHEMBL7435001 | 0.84 | PAX8 (0.50) | HRH1PAX8MEN1DRD2HTR2A | |
| SCHEMBL7438853 | 0.83 | MEN1 (0.49) | HRH1PAX8MEN1HTR1ADRD2 | |
| SCHEMBL7331615 | 0.83 | HRH1 (0.59) | HRH1PAX8MEN1ABCB11CHRM2 | |
| SCHEMBL7436873 | 0.83 | PAX8 (0.47) | HRH1PAX8MEN1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070087-A | Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-12-03 | — | — | US | disclosed |