Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 2/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 13/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450677 | 0.86 | ITGB3 (0.40) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL7455215 | 0.85 | GNAO1 (0.47) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL7446777 | 0.84 | GNAO1 (0.40) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL7448756 | 0.84 | GNAO1 (0.38) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL7454474 | 0.83 | ALDH1A1 (0.37) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL5216607 | 0.83 | GNAO1 (0.36) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL7446660 | 0.82 | ITGB3 (0.36) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL18637787 | 0.81 | ALDH1A1 (0.41) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL7447634 | 0.81 | ITGB3 (0.36) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL7447033 | 0.79 | ITGB3 (0.36) | GNAO1GNAI3GNAI1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-07-04 | — | — | EP | claimed |
| WO-2000015636-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-23 | — | — | WO | claimed |
| EP-1112270-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000015636-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-23 | — | — | WO | disclosed |