Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 4/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.37 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455215 | 0.89 | GNAO1 (0.47) | GNAO1ITGB3ITGA2BF2RGNAI3 | |
| SCHEMBL7448756 | 0.86 | GNAO1 (0.38) | GNAO1ITGB3ITGA2BF2RGNAI3 | |
| SCHEMBL7443444 | 0.85 | ITGB3 (0.35) | GNAO1ITGB3ITGA2BF2RGNAI3 | |
| SCHEMBL7450677 | 0.85 | ITGB3 (0.40) | GNAO1ITGB3ITGA2BF2RGNAI3 | |
| SCHEMBL7447186 | 0.84 | GNAO1 (0.43) | GNAO1ITGB3ITGA2BF2RGNAI3 | |
| SCHEMBL7447634 | 0.82 | ITGB3 (0.36) | GNAO1ITGB3ITGA2BF2RGNAI3 | |
| SCHEMBL7446660 | 0.81 | ITGB3 (0.36) | GNAO1ITGB3ITGA2BF2RGNAI3 | |
| SCHEMBL7454474 | 0.80 | ALDH1A1 (0.37) | GNAO1ITGB3ITGA2BF2RGNAI3 | |
| SCHEMBL7446739 | 0.80 | ITGB3 (0.40) | ITGB3ITGA2BF2RHTR4KDM4E | |
| SCHEMBL5215599 | 0.78 | KDM4E (0.34) | GNAO1GNAI3GNAI1HTR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000015636-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-23 | — | — | WO | disclosed |