Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24097896 | 0.78 | CYP2D6 (0.46) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6060766 | 0.75 | HPGD (0.38) | KDM4EALDH1A1EPHX1HPGDEPHX2 | |
| SCHEMBL4817042 | 0.75 | ADAM17 (0.45) | KDM4EMAPTALDH1A1ADAM17CTSL | |
| SCHEMBL8477947 | 0.74 | KCNA5 (0.45) | KDM4EALDH1A1MEN1KMT2AADAM17 | |
| SCHEMBL31435817 | 0.73 | KDM1A (0.38) | KDM4EALDH1A1MEN1KMT2APDE4B | |
| SCHEMBL28517558 | 0.73 | ADRB2 (0.35) | KDM4EALDH1A1ADAM17EPHX1HPGD | |
| SCHEMBL4817586 | 0.73 | ADAM17 (0.43) | ALDH1A1ADAM17SMN1; SMN2 | |
| SCHEMBL4808147 | 0.72 | ADAM17 (0.47) | KDM4EMAPTALDH1A1ADAM17CYP3A4 | |
| SCHEMBL7098750 | 0.72 | NPC1 (0.44) | MAPTALDH1A1ADAM17HPGDCYP3A4 | |
| Ammonia Solution, Strong SCHEMBL29218401 | 0.72 | MAOA (0.38) | KDM4EMAPTALDH1A1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005446-A1 | N-AROYLPHENYLALANINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010313-A1 | N-AROYLPHENYLALANINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-03-04 | — | — | WO | disclosed |