SCHEMBL7447243

SCHEMBL7447243

O=C(O)CCCNC(=O)C(CCC(=O)O)CCc1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.54
LMNA P02545 1/20 0.54
TSHR P16473 1/20 0.54
MMP8 P22894 1/20 0.53
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
KMT2A Q03164 1/20 0.52
MMP3 P08254 1/20 0.52
HDAC3 O15379 1/20 0.51
MAPK1 P28482 1/20 0.51
ADRA1A P35348 1/20 0.51
HDAC4 P56524 1/20 0.51
SLC6A3 Q01959 1/20 0.51
HDAC1 Q13547 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HDAC7 Q8WUI4 1/20 0.51
HDAC2 Q92769 1/20 0.51
HDAC10 Q969S8 1/20 0.51
HDAC11 Q96DB2 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7435848 0.84 CYP2D6 (0.51) LMNAMMP8CYP2D6CYP2C9CYP2C19
SCHEMBL7431746 0.83 LMNA (0.62) ATMLMNATSHRHDAC3MAPK1
SCHEMBL4780175 0.80 LMNA (0.57) ATMLMNATSHRMMP8CYP2D6
SCHEMBL10395425 0.80 ACE (0.58) MMEACE
SCHEMBL19295758 0.79 TSHR (0.51) TSHRMMP8CYP2D6CYP2C9CYP2C19
SCHEMBL4779824 0.79 LMNA (0.59) ATMLMNATSHRMMP8CYP2D6
SCHEMBL7350860 0.78 CPA3 (0.71) MMP3HDAC3MAPK1ADRA1AHDAC4
SCHEMBL18065701 0.78 MMP8 (0.51) MMP8CYP2D6CYP2C9CYP2C19KMT2A
SCHEMBL18085399 0.78 CYP2C9 (0.57) TSHRMMP8CYP2D6CYP2C9CYP2C19
SCHEMBL18065702 0.78 MMP8 (0.51) MMP8CYP2D6CYP2C9CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5096925-A N-substituted butyramide derivatives CIBA-GEIGY CORPORATION (US) 1992-03-17 US disclosed
US-4939261-A ANALGESICS, ANTIDEPRESSANTS, HYPOTENSIVE AGENTS, NEUROLEPTIC AGENTS CIBA-GEIGY CORPORATION (US) 1990-07-03 US disclosed
EP-0185079-B1 N-SUBSTITUTED BUTYRAMIDE DERIVATIVES CIBA-GEIGY AG (CH) 1988-10-19 EP disclosed
EP-0185079-A1 CIBA GEIGY AG 1986-06-25 EP disclosed
WO-1986000066-A1 N-SUBSTITUTED BUTYRAMIDE DERIVATIVES CIBA-GEIGY AG (CH) 1986-01-03 WO disclosed