Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20545270 | 0.76 | ALDH1A1 (0.58) | ALDH1A1HPGDMAPTL3MBTL1CYP3A4 | |
| SCHEMBL9764276 | 0.75 | ALDH1A1 (0.53) | ALDH1A1MAPTL3MBTL1CYP3A4LMNA | |
| SCHEMBL18919374 | 0.75 | EPHX1 (0.52) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL8679118 | 0.75 | FAAH (0.57) | ALDH1A1HPGDMAPTL3MBTL1CYP1A2 | |
| SCHEMBL1625209 | 0.73 | GAA (0.71) | ALDH1A1HPGDMAPTL3MBTL1CYP1A2 | |
| SCHEMBL16824229 | 0.72 | EPHX1 (0.59) | ALDH1A1HPGDL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL626560 | 0.72 | ALDH1A1 (0.41) | ALDH1A1HPGDMAPTL3MBTL1CYP1A2 | |
| SCHEMBL6924982 | 0.72 | MEN1 (0.67) | ALDH1A1L3MBTL1CYP3A4MEN1KMT2A | |
| SCHEMBL18393929 | 0.72 | MEN1 (0.62) | MEN1KMT2ALMNAGAAHDAC3 | |
| SCHEMBL25600274 | 0.72 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPTL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |