Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324705 | 0.75 | MEN1 (0.49) | MEN1MAPTKMT2AADAMTS5MMP14 | |
| SCHEMBL2116079 | 0.69 | MEN1 (0.49) | MEN1MAPTKMT2ASLC6A2SLC6A4 | |
| SCHEMBL4673538 | 0.68 | MMP2 (0.55) | MEN1MAPTKMT2AADAMTS5MMP14 | |
| SCHEMBL4673540 | 0.68 | MMP2 (0.55) | MEN1MAPTKMT2AADAMTS5MMP14 | |
| SCHEMBL8866292 | 0.67 | GRM5 (0.46) | MEN1MAPTKMT2ASLC6A2SLC6A4 | |
| SCHEMBL4670779 | 0.67 | RORC (0.51) | MEN1MAPTKMT2AADAMTS5MMP14 | |
| SCHEMBL4670781 | 0.67 | RORC (0.51) | MEN1MAPTKMT2AADAMTS5MMP14 | |
| SCHEMBL4671242 | 0.66 | MMP14 (0.52) | MEN1MAPTKMT2AADAMTS5MMP14 | |
| SCHEMBL4671248 | 0.66 | MMP14 (0.52) | MEN1MAPTKMT2AADAMTS5MMP14 | |
| SCHEMBL4673962 | 0.66 | MMP14 (0.52) | MEN1MAPTKMT2AADAMTS5MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |