Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10444182 | 0.92 | REN (0.53) | RENCTSSCTSK | |
| SCHEMBL10444184 | 0.92 | REN (0.53) | RENCTSSCTSK | |
| SCHEMBL10606451 | 0.91 | REN (0.59) | RENCTSSCTSK | |
| SCHEMBL7274022 | 0.85 | CTSS (0.50) | RENCTSSCTSK | |
| SCHEMBL9358862 | 0.85 | CTSS (0.50) | RENCTSSCTSK | |
| SCHEMBL7274017 | 0.85 | CTSS (0.50) | RENCTSSCTSK | |
| SCHEMBL12991841 | 0.83 | REN (0.49) | RENCTSSCTSK | |
| SCHEMBL10609342 | 0.83 | REN (0.46) | RENCTSSCTSK | |
| SCHEMBL7430523 | 0.83 | CTSS (0.52) | RENCTSSCTSK | |
| SCHEMBL10608789 | 0.82 | REN (0.46) | RENCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346887-A | Mixture of tripeptide renin inhibitor and steroid antiinflammatory agent | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| US-5059589-A | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1991-10-22 | — | — | US | disclosed |
| US-5036051-A | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-07-30 | — | — | US | disclosed |
| US-4927807-A | RENIN INHIBITING AMIDES | ABBOTT LABORATORIES (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0311012-A2 | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1989-04-12 | — | — | EP | disclosed |