Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 17/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | CTSE | P14091 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358862 | 1.00 | CTSS (0.50) | CTSSCTSKRENPSEN1PSEN2 | |
| SCHEMBL7274017 | 1.00 | CTSS (0.50) | CTSSCTSKRENPSEN1PSEN2 | |
| SCHEMBL7271038 | 0.93 | REN (0.51) | CTSSCTSKRENPSEN1PSEN2 | |
| SCHEMBL7430523 | 0.90 | CTSS (0.52) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7281729 | 0.89 | REN (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL9833907 | 0.89 | CTSS (0.51) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7284721 | 0.88 | CTSS (0.55) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7440374 | 0.88 | CTSS (0.50) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7437469 | 0.88 | CTSS (0.50) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL10606451 | 0.87 | REN (0.59) | CTSSCTSKRENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| US-4963530-A | Renin inhibitor peptide compounds, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-10-16 | — | — | US | disclosed |
| US-4921855-A | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |
| EP-0283970-A2 | New peptide compounds, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-09-28 | — | — | EP | disclosed |