Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 2/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372480 | 0.91 | BACE1 (0.45) | HRH3KCNH2BACE1LTA4HHRH1 | |
| SCHEMBL7368910 | 0.87 | LTA4H (0.39) | HRH3KCNH2LTA4HSIGMAR1ESR1 | |
| SCHEMBL7373580 | 0.85 | KDM4E (0.45) | HRH3KCNH2ESR1ESR2 | |
| SCHEMBL7368854 | 0.84 | KCNH2 (0.35) | HRH3KCNH2LTA4HESR1ESR2 | |
| SCHEMBL7371832 | 0.82 | SIGMAR1 (0.40) | HRH3KCNH2SIGMAR1 | |
| SCHEMBL7368529 | 0.82 | HRH3 (0.47) | HRH3KCNH2LTA4HSIGMAR1HRH1 | |
| SCHEMBL7371794 | 0.81 | KDM4E (0.40) | LTA4H | |
| SCHEMBL7373311 | 0.81 | ALDH1A1 (0.40) | SIGMAR1ESR1ESR2 | |
| SCHEMBL7369101 | 0.81 | ALDH1A1 (0.40) | ESR1ESR2 | |
| SCHEMBL7373846 | 0.80 | ACP1 (0.38) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994859-A1 | COMPOUNDS | Astra Aktiebolag (publ) (SE) | 2000-04-26 | — | — | EP | claimed |
| WO-1999001437-A1 | COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1999-01-14 | — | — | WO | claimed |