Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677805 | 0.87 | DRD4 (0.42) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL4677803 | 0.87 | DRD4 (0.42) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL4673472 | 0.73 | RORC (0.42) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL4673464 | 0.73 | RORC (0.42) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL4813294 | 0.67 | DRD2 (0.42) | ALDH1A1MAPTKDM4EDRD4TSHR | |
| SCHEMBL4673431 | 0.67 | RORC (0.42) | HDAC8ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4673423 | 0.67 | RORC (0.42) | HDAC8ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4671050 | 0.66 | MMP1 (0.52) | CHRM1RAB9ADRD4DRD2 | |
| SCHEMBL4671045 | 0.66 | MMP1 (0.52) | CHRM1RAB9ADRD4DRD2 | |
| SCHEMBL16938448 | 0.65 | CA2 (0.48) | CYP2C9ALDH1A1RAB9ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |