Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440286 | 0.94 | LMNA (0.35) | TSPOLMNANPC1MAPTRAB9A | |
| SCHEMBL7436061 | 0.82 | KMT2A (0.32) | LMNANPC1MAPTL3MBTL1MEN1 | |
| SCHEMBL9831575 | 0.75 | KDM4E (0.36) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL7435587 | 0.75 | QPCT (0.38) | LMNAHSD17B10 | |
| Water SCHEMBL10786998 | 0.74 | KDM4E (0.38) | LMNASMN1; SMN2MAPTTSHRMEN1 | |
| SCHEMBL7447594 | 0.73 | LCK (0.41) | TSPOSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL7426725 | 0.72 | LMNA (0.43) | TSPOLMNASMN1; SMN2NPC1MAPT | |
| SCHEMBL7446891 | 0.71 | LMNA (0.41) | TSPOLMNASMN1; SMN2NPC1MAPT | |
| SCHEMBL7440283 | 0.69 | KDR (0.44) | LMNAMAPTRAB9ATSHRKDM4E | |
| SCHEMBL7441183 | 0.65 | LMNA (0.39) | TSPOLMNASMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880817-A | O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-14 | — | — | US | claimed |