Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TSPO | P30536 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426725 | 0.83 | LMNA (0.43) | LMNATSPOSMN1; SMN2MAPTNPC1 | |
| SCHEMBL7440283 | 0.83 | KDR (0.44) | LMNAMAPTRAB9APDE10AHSD17B10 | |
| SCHEMBL7447594 | 0.78 | LCK (0.41) | TSPOSMN1; SMN2MAPTPOLBNPC1 | |
| SCHEMBL7441183 | 0.76 | LMNA (0.39) | LMNATSPOSMN1; SMN2MAPTNPC1 | |
| SCHEMBL7440286 | 0.76 | LMNA (0.35) | LMNATSPOMAPTNPC1RAB9A | |
| SCHEMBL9831668 | 0.76 | KMT2A (0.40) | LMNASMN1; SMN2MAPTPOLBNPC1 | |
| SCHEMBL7431845 | 0.74 | HPGD (0.45) | LMNASMN1; SMN2MAPTPOLBPDE10A | |
| SCHEMBL7435587 | 0.73 | QPCT (0.38) | LMNAPDE10AHSD17B10ALDH1A1 | |
| SCHEMBL7436056 | 0.72 | KDR (0.42) | MAPTRAB9APDE10AHSD17B10TSHR | |
| SCHEMBL7447598 | 0.71 | TSPO (0.34) | LMNATSPOSMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880817-A | O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |