Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454492 | 0.76 | ADRA1A (0.36) | ADRA1AADRA1BMAPK1GRM5ALDH1A1 | |
| SCHEMBL7114096 | 0.75 | ADRA1A (0.36) | ADRA1AADRA1BGRM5P2RX7ADRA1D | |
| SCHEMBL7455246 | 0.74 | METAP2 (0.36) | ADRA1AADRA1BMAPK1GRM5ALDH1A1 | |
| SCHEMBL7451102 | 0.74 | ALDH1A1 (0.36) | ADRA1AADRA1BMAPK1GRM5ALDH1A1 | |
| SCHEMBL7447364 | 0.73 | RECQL (0.38) | ADRA1AADRA1BMAPK1ALDH1A1POLB | |
| SCHEMBL7447711 | 0.72 | ALDH1A1 (0.38) | ADRA1AADRA1BMAPK1GRM5ALDH1A1 | |
| SCHEMBL5829689 | 0.68 | ADRA1A (0.34) | ADRA1AADRA1BP2RX7ALOX5APFEN1 | |
| SCHEMBL10513692 | 0.67 | — | — | |
| SCHEMBL17591534 | 0.67 | HSD17B10 (0.55) | ADRA1AADRA1BALDH1A1POLBHPGD | |
| SCHEMBL30636365 | 0.67 | HSD17B10 (0.55) | ADRA1AADRA1BALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009485-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |