Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 4/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449276 | 0.83 | LTB4R2 (0.43) | LTB4R2MEN1KMT2APTGDR2NOS2 | |
| SCHEMBL7445917 | 0.76 | LTB4R2 (0.40) | LTB4R2MEN1KMT2APTGDR2NOS2 | |
| SCHEMBL7456591 | 0.74 | LTB4R2 (0.39) | LTB4R2MEN1KMT2APTGDR2USP2 | |
| SCHEMBL7447611 | 0.70 | — | — | |
| SCHEMBL7451547 | 0.70 | ALDH1A1 (0.36) | MEN1KMT2APTGDR2ALDH1A1 | |
| SCHEMBL20218879 | 0.69 | MEN1 (0.52) | LTB4R2MEN1KMT2APTGDR2NOS2 | |
| SCHEMBL7453001 | 0.69 | ALDH1A1 (0.36) | MEN1KMT2APTGDR2ALDH1A1 | |
| SCHEMBL6635073 | 0.67 | LTB4R2 (0.43) | LTB4R2MEN1KMT2APTGDR2TP53 | |
| SCHEMBL14229341 | 0.66 | LTB4R2 (0.58) | LTB4R2ALDH1A1TP53 | |
| SCHEMBL18464228 | 0.65 | LTB4R2 (0.50) | LTB4R2MEN1KMT2APTGDR2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541151-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |