Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449276 | 0.82 | LTB4R2 (0.43) | LTB4R2MEN1KMT2APTGDR2TP53 | |
| SCHEMBL7447923 | 0.74 | LTB4R2 (0.41) | LTB4R2MEN1KMT2APTGDR2TP53 | |
| SCHEMBL7445917 | 0.72 | LTB4R2 (0.40) | LTB4R2MEN1KMT2APTGDR2 | |
| SCHEMBL7453001 | 0.68 | ALDH1A1 (0.36) | MEN1KMT2APTGDR2ALDH1A1KDM4E | |
| SCHEMBL14229341 | 0.66 | LTB4R2 (0.58) | LTB4R2TP53ALDH1A1 | |
| SCHEMBL6298905 | 0.65 | CNR2 (0.48) | — | |
| SCHEMBL7456043 | 0.64 | ATM (0.39) | KDM4EHSD17B10LMNA | |
| SCHEMBL7451547 | 0.64 | ALDH1A1 (0.36) | MEN1KMT2APTGDR2ALDH1A1KDM4E | |
| SCHEMBL20218879 | 0.64 | MEN1 (0.52) | LTB4R2MEN1KMT2APTGDR2TP53 | |
| SCHEMBL3403136 | 0.63 | MEN1 (0.38) | LTB4R2MEN1KMT2APTGDR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |