Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 3/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451547 | 0.87 | ALDH1A1 (0.36) | ALDH1A1KDM4ETSHRHSD17B10GAA | |
| SCHEMBL7449276 | 0.85 | LTB4R2 (0.43) | ALDH1A1MPOPTGDR2MEN1KMT2A | |
| SCHEMBL7456043 | 0.70 | ATM (0.39) | KDM4EHSD17B10RAB9A | |
| SCHEMBL7447923 | 0.69 | LTB4R2 (0.41) | ALDH1A1PTGDR2MEN1KMT2A | |
| SCHEMBL7456591 | 0.68 | LTB4R2 (0.39) | ALDH1A1KDM4ETSHRHSD17B10GAA | |
| SCHEMBL7445917 | 0.65 | LTB4R2 (0.40) | PTGDR2MEN1KMT2A | |
| SCHEMBL6304818 | 0.65 | PPARG (0.37) | ALDH1A1KDM4EPTGDR2RAB9A | |
| SCHEMBL7454918 | 0.63 | KDM4E (0.34) | ALDH1A1KDM4EHSD17B10GAAMPO | |
| SCHEMBL5103828 | 0.61 | AGTR1 (0.40) | PTGDR2KMT2A | |
| SCHEMBL1715539 | 0.61 | HRH4 (0.41) | ALDH1A1PTGDR2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541151-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |