Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.59 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.59 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.59 |
| ▸ | MME | P08473 | 4/20 | 0.58 |
| ▸ | ACE | P12821 | 4/20 | 0.58 |
| ▸ | CPA1 | P15085 | 2/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.58 |
| ▸ | ANPEP | P15144 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | FCER2 | P06734 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.56 |
| ▸ | ITGAV | P06756 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | IL2 | P60568 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563448 | 0.86 | ALDH1A1 (0.83) | ALDH1A1PSMB5ANPEPATMKMT2A | |
| SCHEMBL8022139 | 0.86 | ALDH1A1 (0.83) | ALDH1A1PSMB5ANPEPATMKMT2A | |
| SCHEMBL6020596 | 0.85 | CTSB (0.70) | PSMB1PSMB5PSMB2ANPEPFCER2 | |
| SCHEMBL9554537 | 0.83 | ALDH1A1 (0.80) | ALDH1A1MMEACECPA1ACE2 | |
| SCHEMBL1060389 | 0.83 | MME (0.56) | MMEACECPA1ACE2FCER2 | |
| SCHEMBL2888909 | 0.83 | MME (0.56) | MMEACECPA1ACE2FCER2 | |
| SCHEMBL6020170 | 0.82 | CTSS (0.58) | ALDH1A1PSMB1PSMB5PSMB2MME | |
| SCHEMBL22764712 | 0.82 | MME (0.64) | MMEACECPA1ACE2KMT2A | |
| SCHEMBL8201136 | 0.82 | FCER2 (0.69) | PSMB1PSMB5PSMB2MMEACE | |
| SCHEMBL8201134 | 0.82 | FCER2 (0.69) | PSMB1PSMB5PSMB2MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950046-B1 | 3,4-DISUBSTITUTED AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE REGULATORS | NAEJA PHARMACEUTICAL INC (CA) | 2002-04-10 | — | — | EP | disclosed |
| EP-0950046-A1 | 3,4-DISUBSTITUTED AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE REGULATORS | SYNPHAR LABORATORIES INC. (CA) | 1999-10-20 | — | — | EP | disclosed |
| US-5959123-A | REACATING SUBSTITUTED AMINO ACID WITH 3-AMINO-4-SUBSTITUTED-AZETIDINE-2-ONE COMPOUND TO FORM 3, 4-DISUBSTITUTED-AZETIDINE-2-ONE COMPOUND; USEFUL FOR TREATING MUSCULAR DYSTROPHY, ARTHRITIS, VIRAL AND PARASITIC INFECTIONS | SYNPHAR LABORATORIES, INC. (CA) | 1999-09-28 | — | — | US | disclosed |
| WO-1998012176-A1 | 3,4-DISUBSTITUTED AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE REGULATORS | SYNPHAR LABORATORIES INC. (US) | 1998-03-26 | — | — | WO | disclosed |