SCHEMBL7448065

SCHEMBL7448065

CC(C)CC1(CCc2ccccc2)CC(O)=C(Sc2conc2C(C)C)C(=O)O1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 18/20 0.36
LDHB P07195 9/20 0.35
MLNR O43193 1/20 0.32
NR1I2 O75469 1/20 0.32
ABCB11 O95342 1/20 0.32
PGR P06401 1/20 0.32
CTSD P07339 1/20 0.32
CHRM2 P08172 1/20 0.32
ADRA2A P08913 1/20 0.32
PGA5 P0DJD9 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
CTSE P14091 1/20 0.32
GABRA1 P14867 1/20 0.32
ADRA2C P18825 1/20 0.32
DRD1 P21728 1/20 0.32
HTR2A P28223 1/20 0.32
AGTR1 P30556 1/20 0.32
CCKAR P32238 1/20 0.32
ADRA1A P35348 1/20 0.32
PTGS2 P35354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7450770 0.80 LDHA (0.36) LDHALDHBMLNRNR1I2ABCB11
SCHEMBL7440959 0.74 LDHA (0.41) LDHALDHBMLNRNR1I2ABCB11
SCHEMBL9199838 0.72 GAA (0.35) MLNRNR1I2ABCB11PGRCTSD
SCHEMBL6173128 0.71 OPRD1 (0.41) MLNRNR1I2ABCB11PGRCTSD
SCHEMBL6177878 0.71 MLNR (0.38) MLNRNR1I2ABCB11PGRCTSD
SCHEMBL6176450 0.70 MLNR (0.49) MLNRNR1I2ABCB11PGRCTSD
SCHEMBL7443043 0.70 MLNR (0.42) MLNRNR1I2ABCB11PGRCTSD
SCHEMBL7998725 0.69 LDHA (0.34) LDHALDHBMLNRNR1I2ABCB11
SCHEMBL9195762 0.69 PRKCA (0.35) MLNRNR1I2ABCB11PGRCTSD
SCHEMBL7444813 0.69 KMT2A (0.38) MLNRNR1I2ABCB11PGRCTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729463-B1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2002-05-22 EP claimed
EP-0729463-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & COMPANY (US) 1996-09-04 EP claimed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO claimed
EP-0729463-B1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2002-05-22 EP disclosed
US-5936128-A BENZENETHIOL COMPOUNDS AS INTERMEDIATES; BACTERICIDES, VIRICIDES; HIV WARNER-LAMBERT COMPANY (US) 1999-08-10 US disclosed
US-5840751-A ADMINISTERING IN THE TREATMENT OF INFECTION OR DISEASE CAUSED BY A RETROVIRUS WARNER-LAMBERT COMPANY (US) 1998-11-24 US disclosed
US-5789440-A 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents WARNER-LAMBERT COMPANY (US) 1998-08-04 US disclosed
EP-0729463-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729464-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014012-A1 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014011-A2 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed