Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441056 | 0.90 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTHTTL3MBTL1 | |
| Ethane SCHEMBL7485196 | 0.87 | HSP90AA1 (0.39) | ALDH1A1LMNAMAPTHTTTDP1 | |
| SCHEMBL7450446 | 0.86 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTHTTHSP90AA1 | |
| SCHEMBL7432830 | 0.85 | PTGER2 (0.37) | ALDH1A1LMNAMAPTHTTMEN1 | |
| SCHEMBL7437314 | 0.85 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTHTTL3MBTL1 | |
| SCHEMBL7444165 | 0.85 | PDE4B (0.40) | ALDH1A1LMNAMAPTHTTTDP1 | |
| SCHEMBL7437641 | 0.84 | LMNA (0.38) | ALDH1A1LMNAMAPTHTTMEN1 | |
| SCHEMBL7445404 | 0.83 | PARP1 (0.37) | ALDH1A1LMNAMAPTHTTL3MBTL1 | |
| SCHEMBL7445970 | 0.83 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPTHTTTDP1 | |
| SCHEMBL7448174 | 0.82 | HSP90AA1 (0.38) | ALDH1A1LMNAMAPTHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |