Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441063 | 0.90 | KCNK3 (0.36) | HPGDALDH1A1PDE4B | |
| SCHEMBL7443321 | 0.90 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1HPGDHSD17B10MEN1 | |
| SCHEMBL6175973 | 0.86 | HSD11B1 (0.39) | HSP90AA1HSP90AB1HPGDHSD17B10MEN1 | |
| SCHEMBL7450449 | 0.86 | MEN1 (0.37) | HSP90AA1HSP90AB1MEN1KMT2AL3MBTL1 | |
| Ethane SCHEMBL7485196 | 0.85 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1HPGDHSD17B10MEN1 | |
| SCHEMBL7437319 | 0.85 | ALDH1A1 (0.36) | MAPTALDH1A1LMNAHTTTP53 | |
| SCHEMBL7437644 | 0.84 | EEF2K (0.41) | HSD11B1 | |
| SCHEMBL7445975 | 0.84 | POLB (0.38) | KMT2AALDH1A1LMNAHTTTDP1 | |
| SCHEMBL7448164 | 0.82 | ALDH1A1 (0.40) | HSP90AA1HSP90AB1HPGDHSD17B10MEN1 | |
| SCHEMBL7448162 | 0.80 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |