Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.46 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492997 | 0.84 | FKBP1A (0.57) | LMNATP53CASP1CASP7SMN1; SMN2 | |
| SCHEMBL5497978 | 0.83 | FKBP1A (0.52) | LMNATP53CASP1CASP7SMN1; SMN2 | |
| SCHEMBL5499031 | 0.83 | LMNA (0.57) | LMNATP53CASP1CASP7SMN1; SMN2 | |
| SCHEMBL6709564 | 0.81 | ITGA4 (0.57) | FKBP1AITGA4ITGB1ITGA2ITGA5 | |
| SCHEMBL6710636 | 0.81 | ITGA4 (0.57) | FKBP1AITGA4ITGB1ITGA2ITGA5 | |
| SCHEMBL5496192 | 0.80 | ITGA4 (0.56) | FKBP1AITGA4ITGB1ITGA2ITGA5 | |
| SCHEMBL6151165 | 0.78 | ITGA4 (0.58) | FKBP1AITGA4ITGB1ITGA2ITGA5 | |
| SCHEMBL6151162 | 0.78 | ITGA4 (0.58) | FKBP1AITGA4ITGB1ITGA2ITGA5 | |
| SCHEMBL5494189 | 0.78 | FKBP1A (0.67) | LMNATP53CASP1CASP7SMN1; SMN2 | |
| SCHEMBL6710949 | 0.77 | GAA (0.60) | FKBP1AITGA4ITGB1ITGA2ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001971-A1 | DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006432-A1 | DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 1999-02-11 | — | — | WO | claimed |
| EP-1001971-A1 | DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006432-A1 | DIPEPTIDE AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 1999-02-11 | — | — | WO | disclosed |