SCHEMBL7448699

SCHEMBL7448699

CCCN(CCC)C1Cc2cc3c(cc2C1)C(=O)N(Cc1ccc(C(=O)OC)cc1)C3=O

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
CA4 P22748 1/20 0.49
CA9 Q16790 1/20 0.49
DRD3 P35462 4/20 0.46
DRD2 P14416 3/20 0.46
ALDH1A1 P00352 2/20 0.44
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
ALOX15 P16050 1/20 0.43
MAPK1 P28482 1/20 0.43
FYN P06241 1/20 0.42
NPC1 O15118 1/20 0.42
LMNA P02545 1/20 0.42
HTT P42858 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7456265 0.87 DRD3 (0.54) CA1CA2CA4CA9DRD3
SCHEMBL7451238 0.85 DRD2 (0.51) DRD3DRD2ALDH1A1CYP2D6CYP2C9
SCHEMBL7456278 0.83 DRD3 (0.50) DRD3DRD2ALDH1A1CYP2D6CYP2C9
SCHEMBL7451624 0.82 FYN (0.45) DRD3DRD2ALDH1A1CYP2D6CYP2C9
SCHEMBL8103965 0.82 ALDH1A1 (0.55) DRD3DRD2ALDH1A1CYP2D6CYP2C9
SCHEMBL8094262 0.81 CHRM5 (0.47) DRD3DRD2ALDH1A1CYP2D6CYP2C9
SCHEMBL7459110 0.81 ALDH1A1 (0.57) ALDH1A1CYP2D6CYP2C9ALOX15MAPK1
SCHEMBL7443295 0.80 FYN (0.45) DRD3DRD2ALDH1A1CYP2D6CYP2C9
SCHEMBL7448204 0.80 FYN (0.42) DRD3ALDH1A1CYP2D6CYP2C9ALOX15
SCHEMBL7456004 0.79 CA1 (0.56) CA1CA2CA4CA9DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6084130-A FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS PHARMACIA & UPJOHN COMPANY (US) 2000-07-04 US disclosed
EP-0923542-A1 ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS PHARMACIA & UPJOHN COMPANY (US) 1999-06-23 EP disclosed
WO-1997045403-A1 ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS PHARMACIA & UPJOHN COMPANY (US) 1997-12-04 WO disclosed