Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.60 |
| ▸ | CTSK | P43235 | 11/20 | 0.60 |
| ▸ | CTSS | P25774 | 7/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533828 | 0.86 | ALDH1A1 (0.61) | CTSLCTSKCTSSCTSBALDH1A1 | |
| SCHEMBL7452671 | 0.81 | CTSK (0.51) | CTSLCTSKCTSSCTSBPOLB | |
| SCHEMBL7444712 | 0.81 | CTSK (0.51) | CTSLCTSKCTSSCTSBPOLB | |
| SCHEMBL8086163 | 0.79 | CTSK (0.79) | CTSLCTSKCTSSCTSB | |
| SCHEMBL7318397 | 0.79 | CTSK (0.62) | CTSLCTSKCTSSCTSBMMP9 | |
| SCHEMBL7447893 | 0.78 | CTSK (0.61) | CTSLCTSKCTSSCTSBMMP2 | |
| SCHEMBL7444722 | 0.78 | CTSK (0.83) | CTSLCTSKCTSSCTSBF2 | |
| SCHEMBL7161878 | 0.77 | CTSK (0.72) | CTSLCTSKCTSSCTSB | |
| SCHEMBL7452773 | 0.77 | CTSK (0.53) | CTSLCTSKCTSSCTSB | |
| SCHEMBL7290941 | 0.76 | MMP2 (0.71) | NPY5RPOLBF2ALDH1A1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817795-B1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | NAEJA PHARMACEUTICAL INC (CA) | 2000-11-15 | — | — | EP | claimed |
| US-5986108-A | ENZYME INHIBITORS | SYNPHAR LABORATORIES, INC. (CA) | 1999-11-16 | — | — | US | claimed |
| EP-0817795-B1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | NAEJA PHARMACEUTICAL INC (CA) | 2000-11-15 | — | — | EP | disclosed |
| US-5986108-A | ENZYME INHIBITORS | SYNPHAR LABORATORIES, INC. (CA) | 1999-11-16 | — | — | US | disclosed |
| EP-0817795-A1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | SYNPHAR LABORATORIES INC. (CA) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996032408-A1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | SYNPHAR LABORATORIES, INC. (US) | 1996-10-17 | — | — | WO | disclosed |