Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.54 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454592 | 0.89 | GRM5 (0.68) | GRM5METSMARCA2SMARCA4TP53 | |
| SCHEMBL7458429 | 0.87 | GRM5 (0.61) | GRM5SORT1MEN1KMT2ASMARCA2 | |
| SCHEMBL7453711 | 0.87 | GRM5 (0.58) | GRM5SORT1MEN1KMT2ASMARCA2 | |
| SCHEMBL7454077 | 0.87 | GRM5 (0.58) | GRM5SORT1METMEN1KMT2A | |
| SCHEMBL12067825 | 0.82 | GRM5 (0.52) | GRM5MEN1KMT2ATP53MAPT | |
| SCHEMBL7449902 | 0.82 | GRM5 (0.46) | GRM5SORT1MEN1KMT2ASMARCA2 | |
| SCHEMBL7459153 | 0.78 | GRM5 (0.72) | GRM5MEN1KMT2ASMARCA2SMARCA4 | |
| SCHEMBL7453851 | 0.78 | GRM5 (0.69) | GRM5SMARCA2SMARCA4NPC1USP2 | |
| SCHEMBL7458646 | 0.77 | GRM5 (0.73) | GRM5MEN1KMT2ASMARCA2SMARCA4 | |
| SCHEMBL7454043 | 0.74 | GRM5 (0.71) | GRM5METMEN1KMT2ASMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |