Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.41 |
| ▸ | SDCBP | O00560 | 1/20 | 0.39 |
| ▸ | SDC2 | P34741 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450219 | 1.00 | P2RX3 (0.43) | P2RX3NOTUMSDCBPSDC2HSD17B3 | |
| SCHEMBL7454667 | 1.00 | P2RX3 (0.43) | P2RX3NOTUMSDCBPSDC2HSD17B3 | |
| SCHEMBL662289 | 0.87 | NOTUM (0.40) | P2RX3NOTUMHSD17B3KMT2AMEN1 | |
| SCHEMBL663054 | 0.87 | NOTUM (0.40) | P2RX3NOTUMHSD17B3KMT2AMEN1 | |
| SCHEMBL661224 | 0.87 | NOTUM (0.40) | P2RX3NOTUMHSD17B3KMT2AMEN1 | |
| SCHEMBL12571559 | 0.87 | NOTUM (0.40) | P2RX3NOTUMHSD17B3KMT2AMEN1 | |
| SCHEMBL9108805 | 0.84 | P2RX3 (0.43) | P2RX3NOTUMSDCBPSDC2MAPT | |
| SCHEMBL2003570 | 0.83 | P2RX3 (0.42) | P2RX3NOTUMHSD17B3KMT2AMEN1 | |
| SCHEMBL14615590 | 0.83 | BMPR1B (0.49) | P2RX3NOTUMKMT2AMEN1MAPT | |
| SCHEMBL4553514 | 0.79 | NOTUM (0.53) | NOTUMKMT2AMEN1MAPTOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103119015-A | Method for resolving nitrogen substituted -5-alkoxy-2-aminotetralin derivatives | UCB PHARMA GMBH | 2013-05-22 | — | — | CN | claimed |
| US-20130102794-A1 | Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives | UCB PHARMA GMBH (DE) | 2013-04-25 | — | — | US | claimed |
| EP-2585428-B1 | PROCESSES FOR THE RESOLUTION OF NITROGEN SUBSTITUTED (S)-5-ALKOXY-2-AMINOTETRALIN DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2017-05-10 | — | — | EP | disclosed |
| US-8981121-B2 | Process for the preparation of nitrogen substituted aminotetralins derivatives | UCB PHARMA GMBH (DE) | 2015-03-17 | — | — | US | disclosed |
| CN-103119015-A | Method for resolving nitrogen substituted -5-alkoxy-2-aminotetralin derivatives | UCB PHARMA GMBH | 2013-05-22 | — | — | CN | disclosed |
| EP-2585428-A2 | PROCESSES FOR THE RESOLUTION OF NITROGEN SUBSTITUTED (S)-5-ALKOXY-2-AMINOTETRALIN DERIVATIVES | UCB Pharma GmbH (DE) | 2013-05-01 | — | — | EP | disclosed |
| US-20130102794-A1 | Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives | UCB PHARMA GMBH (DE) | 2013-04-25 | — | — | US | disclosed |
| WO-2011161255-A2 | NOVEL PROCESS FOR THE PREPARATION OF NITROGEN SUBSTITUTED AMINOTETRALINS DERIVATIVES | UCB PHARMA GMBH (DE) | 2011-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102794-A1 | Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives | AANAT, AADAT, ASNS | P2RX3 3694/4885NOTUM 3223/4885SDCBP 4582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.