SCHEMBL7450481

SCHEMBL7450481

O=c1cc(CCl)c2cc(Br)c(O)cc2o1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 9/20 0.77
AKR1B1 P15121 2/20 0.51
PON1 P27169 2/20 0.48
DYRK1A Q13627 1/20 0.48
TDP1 Q9NUW8 1/20 0.44
KDM4E B2RXH2 4/20 0.42
ALDH1A1 P00352 3/20 0.42
HPGD P15428 3/20 0.42
HSD17B10 Q99714 3/20 0.42
CYP3A4 P08684 1/20 0.42
THRB P10828 1/20 0.42
GLA P06280 2/20 0.42
GAA P10253 2/20 0.42
CASP1 P29466 2/20 0.42
CASP7 P55210 2/20 0.42
POLB P06746 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HSD17B3 P37058 1/20 0.42
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8702627 0.87 MCL1 (1.00) MCL1AKR1B1PON1DYRK1ATDP1
SCHEMBL7462235 0.86 MCL1 (0.76) MCL1AKR1B1TDP1KDM4EALDH1A1
SCHEMBL30350025 0.86 MCL1 (0.76) MCL1AKR1B1TDP1KDM4EALDH1A1
SCHEMBL13058664 0.86 HSD17B3 (0.58) MCL1AKR1B1KDM4EALDH1A1HPGD
SCHEMBL17553159 0.86 MCL1 (0.57) MCL1AKR1B1TDP1KDM4EALDH1A1
SCHEMBL7459151 0.83 MCL1 (0.79) MCL1AKR1B1PON1DYRK1ATDP1
SCHEMBL31437397 0.82 MCL1 (0.69) MCL1AKR1B1TDP1KDM4EALDH1A1
SCHEMBL9277841 0.81 MCL1 (0.77) MCL1AKR1B1PON1DYRK1AKDM4E
SCHEMBL14930073 0.81 HSD17B3 (0.63) MCL1AKR1B1KDM4EALDH1A1HPGD
SCHEMBL299767 0.80 MCL1 (0.50) MCL1AKR1B1TDP1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250189894-A1 PHOTOSENSITIVE SURFACE TREATING AGENT, PATTERN FORMATION SUBSTRATE, LAMINATE, TRANSISTOR, PATTERN FORMING METHOD AND METHOD OF PRODUCING TRANSISTOR NIKON CORPORATION (JP) 2025-06-12 US disclosed
CN-119631019-A Photosensitive surface treatment agent, substrate for pattern formation, laminate, transistor, pattern formation method, and method for manufacturing transistor 株式会社 尼康 2025-03-14 CN disclosed
WO-2024043221-A1 PHOTOSENSITIVE SURFACE TREATMENT AGENT, PATTERN FORMATION SUBSTRATE, LAMINATE, TRANSISTOR, PATTERN FORMATION METHOD, AND TRANSISTOR MANUFACTURING METHOD 株式会社ニコン 2024-02-29 WO disclosed
WO-2024043221-A1 PHOTOSENSITIVE SURFACE TREATMENT AGENT, PATTERN FORMATION SUBSTRATE, LAMINATE, TRANSISTOR, PATTERN FORMATION METHOD, AND TRANSISTOR MANUFACTURING METHOD 株式会社ニコン 2024-02-29 WO disclosed
US-9724417-B2 Nanocarriers with multi-photon response elements THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-08-08 US disclosed
US-8828383-B2 Nanocarriers with multi-photon response elements THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-09-09 US disclosed
US-8629197-B2 Chemically patterned hydrogels, manufacture and use thereof SHOICHET MOLLY (CA) 2014-01-14 US disclosed
US-8629197-B2 Chemically patterned hydrogels, manufacture and use thereof SHOICHET MOLLY (CA) 2014-01-14 US disclosed
US-20120259267-A1 Chemically Amplified Response Strategies for Medical Sciences THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-10-11 US disclosed
US-7507859-B2 Functional synthetic molecules and macromolecules for gene delivery FIFTH BASE LLC (US) 2009-03-24 US disclosed
US-7507859-B2 Functional synthetic molecules and macromolecules for gene delivery FIFTH BASE LLC (US) 2009-03-24 US disclosed
US-20080286360-A1 Chemically patterned hydrogels, manufacture and use thereof SHOICHET MOLLY 2008-11-20 US disclosed
US-20080286360-A1 Chemically patterned hydrogels, manufacture and use thereof SHOICHET MOLLY 2008-11-20 US disclosed
US-6472541-B2 HALOGENATED- COUMARIN, QUINOLINE-2-ONE, XANTHENE, THIOXANTHENE, SELENOXANTHENEN, OR ANTHRACENE DERIVATIVES; IRRADIATING TO CONTROL THE RELEASE OF THE SOMPOUND SPATIALLY AND TEMPORALLY TO PROBE ITS BIOLOGICAL EFFECTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2002-10-29 US disclosed
EP-1151350-A4 PROTECTING GROUPS WITH INCREASED PHOTOSENSITIVITIES UNIV CALIFORNIA (US) 2002-08-21 EP disclosed
US-20020016472-A1 PROTECTING GROUPS WITH INCREASED PHOTOSENSITIVITIES REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE 2002-02-07 US disclosed
EP-1151350-A1 PROTECTING GROUPS WITH INCREASED PHOTOSENSITIVITIES The Regents of the University of California (US) 2001-11-07 EP disclosed
WO-2000031588-A1 PROTECTING GROUPS WITH INCREASED PHOTOSENSITIVITIES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-06-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120259267-A1 Chemically Amplified Response Strategies for Medical Sciences CGAS, STING1, TLR3 MCL1 363/4885AKR1B1 4313/4885PON1 4668/4885
US-20080286360-A1 Chemically patterned hydrogels, manufacture and use thereof CD44, CRYAA, VCL MCL1 2839/4885AKR1B1 4828/4885PON1 2963/4885
US-20020016472-A1 PROTECTING GROUPS WITH INCREASED PHOTOSENSITIVITIES ERCC4, XPA, GPX4 MCL1 1400/4885AKR1B1 2111/4885PON1 44/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.