Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.34 |
| ▸ | PTPN4 | P29074 | 3/20 | 0.34 |
| ▸ | PTPN9 | P43378 | 3/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445280 | 0.90 | MAT2A (0.38) | MAT2AEGLN1KDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL7443975 | 0.89 | MAT2A (0.38) | MAT2AEGLN1KDM4EALDH1A1GAA | |
| SCHEMBL7283343 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL7276889 | 0.79 | AGTR1 (0.46) | — | |
| SCHEMBL7331126 | 0.79 | KDM4E (0.42) | MAT2AKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL7274884 | 0.78 | DCTPP1 (0.45) | MAT2AKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL7274709 | 0.78 | PPARG (0.52) | — | |
| SCHEMBL7435415 | 0.78 | KDM4E (0.40) | MAT2AEGLN1KDM4EALDH1A1GAA | |
| SCHEMBL9350388 | 0.77 | CCR2 (0.43) | EGLN1 | |
| SCHEMBL9430324 | 0.76 | PTGDR2 (0.39) | EGLN1ALDH1A1MAPTSMN1; SMN2SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705100-A4 | THERAPEUTIC SUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-05-29 | — | — | EP | disclosed |
| EP-0705100-A1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-04-10 | — | — | EP | disclosed |
| WO-1994027591-A1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| WO-1993024501-A1 | PHOSPHORUS CONTAINING HETEROCYCLIC COMPOUNDS AS ANGIOTENSINS ANTAGONISTS | ZENECA LIMITED (GB) | 1993-12-09 | — | — | WO | disclosed |