Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 7/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451341 | 0.86 | GRM5 (0.53) | GRM5SMARCA2SMARCA4NPC1USP2 | |
| SCHEMBL7453227 | 0.84 | GRM5 (0.47) | GRM5SMARCA2SMARCA4HDAC4MAPT | |
| SCHEMBL7454592 | 0.78 | GRM5 (0.68) | GRM5SMARCA2SMARCA4NPC1USP2 | |
| SCHEMBL7454850 | 0.78 | GRM5 (0.52) | GRM5SMARCA2SMARCA4NPC1USP2 | |
| SCHEMBL7449902 | 0.77 | GRM5 (0.46) | GRM5SMARCA2SMARCA4NPC1USP2 | |
| SCHEMBL7446764 | 0.76 | GRM5 (0.52) | GRM5SMARCA2SMARCA4NPC1MAPT | |
| SCHEMBL7451159 | 0.74 | GRM5 (0.60) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL7451577 | 0.74 | GRM5 (0.55) | GRM5SMARCA2SMARCA4HDAC4NPC1 | |
| SCHEMBL12067831 | 0.72 | L3MBTL1 (0.45) | NPC1LMNATP53MAPTHTT | |
| SCHEMBL7447799 | 0.71 | GRM5 (0.44) | GRM5SMARCA2SMARCA4NPC1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | claimed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |