Sugi Predict

Sugi Predict / Compounds / SCHEMBL745185

SCHEMBL745185

SCHEMBL745185

FC(F)(F)COc1[c]cccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR3 P46089 1/20 0.36
▸ MAPT P10636 3/20 0.34
▸ MEN1 O00255 3/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ ALDH1A1 P00352 3/20 0.34
▸ L3MBTL1 Q9Y468 3/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ USP2 O75604 1/20 0.34
▸ HSP90AA1 P07900 1/20 0.34
▸ HSP90AB1 P08238 1/20 0.34
▸ THRB P10828 1/20 0.34
▸ G6PD P11413 1/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ CASP1 P29466 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ LMNA P02545 3/20 0.34
▸ S1PR2 O95136 1/20 0.34
▸ S1PR4 O95977 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ XBP1 P17861 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4530486 0.82 CFTR (0.39) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL3079151 0.81 MCHR1 (0.36) —
SCHEMBL292905 0.80 GABRP (0.33) ALDH1A1SMN1; SMN2NPSR1
SCHEMBL7651552 0.79 — —
SCHEMBL9859940 0.79 USP2 (0.31) MAPTUSP2TSHR
SCHEMBL3022736 0.77 MAPT (0.38) GPR3MAPTMEN1KMT2AALDH1A1
SCHEMBL452876 0.77 — —
SCHEMBL6238419 0.76 JAK2 (0.33) MAPTALDH1A1KDM4ELMNAGAA
SCHEMBL17103367 0.76 — —
SCHEMBL7024874 0.75 IDO1 (0.53) ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 273 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240002395-A1 COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN THE JOHNS HOPKINS UNIVERSITY 2024-01-04 — — US claimed
EP-4255893-A1 COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN The Johns Hopkins University (US) 2023-10-11 — — EP claimed
US-11731954-B2 Histone demethylase inhibitors CELGENE QUANTICEL RES INC (US) 2023-08-22 — — US claimed
WO-2022119823-A1 COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN THE JOHNS HOPKINS UNIVERSITY (US) 2022-06-09 — — WO claimed
US-20210238161-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2021-08-05 — — US claimed
US-11001568-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2021-05-11 — — US claimed
US-20200157077-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2020-05-21 — — US claimed
EP-3397617-A1 HISTONE DEMETHYLASE INHIBITORS Celgene Quanticel Research, Inc. (US) 2018-11-07 — — EP claimed
US-10059687-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2018-08-28 — — US claimed
US-9862691-B2 Cyclic triazo and diazo sodium channel blockers UNIVERSITY OF GREENWICH (GB) 2018-01-09 — — US claimed
US-RE37087-E1 1-(4-ETHOXYPHENYL)-4-(4-FLUORO-3-PHENOXYPHENYL)-1 -TRIFLUOROMETHYLBUTANE OR 1-(4-ETHOXY-3-FLUOROPHENYL)-4-(3-PHENOXYPHENYL)-1-TRIFLUOROMETHYLBUTANE, FOR EXAMPLE; COMBATS INSECTS AND MITES SCHERING AKTIENGESELLSCHAFT (DE) 2001-03-06 — — US claimed
WO-2000078733-A1 PHENOXY FLUOROPYRIMIDINES BAYER AKTIENGESELLSCHAFT (DE) 2000-12-28 — — WO claimed
EP-1000045-A1 1,4-DISUBSTITUTED PIPERAZINES RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) 2000-05-17 — — EP claimed
WO-1999006382-A1 1,4-DISUBSTITUTED PIPERAZINES RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) 1999-02-11 — — WO claimed
EP-0233834-B1 INSECTICIDAL TRIFLUORMETHYL ALKANE DERIVATIVES SCHERING AKTIENGESELLSCHAFT (DE) 1992-04-22 — — EP claimed
EP-0177965-B1 NOVEL OXA- AND THIADIAZOLYL DERIVATIVES AND THEIR USE SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1990-03-21 — — EP claimed
US-4791123-A MITICIDES SCHERING AKT. (DE) 1988-12-13 — — US claimed
US-4743622-A FLUORO COMPOUNDS SCHERING AKTIENGESELLSCHAFT (DE) 1988-05-10 — — US claimed
EP-0233834-A1 Insecticidal trifluormethyl alkane derivatives SCHERING AKTIENGESELLSCHAFT (DE) 1987-08-26 — — EP claimed
EP-0191723-A1 Aromatic alkane derivatives, pesticides containing these compounds and processes for their production SCHERING AKTIENGESELLSCHAFT (DE) 1986-08-20 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001568-B2 Histone demethylase inhibitors KDM1B, KDM1A, BMI1 GPR3 3139/4885MAPT 2586/4885MEN1 385/4885
US-11731954-B2 Histone demethylase inhibitors KDM1B, KDM1A, BMI1 GPR3 3139/4885MAPT 2586/4885MEN1 385/4885
US-20240002395-A1 COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN MRGPRX1, MRGPRX4, MRGPRX2 GPR3 27/4885MAPT 2335/4885MEN1 2729/4885
US-10059687-B2 Histone demethylase inhibitors KDM1B, KDM1A, BMI1 GPR3 3139/4885MAPT 2586/4885MEN1 385/4885
US-20200157077-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM1A, BMI1 GPR3 3139/4885MAPT 2586/4885MEN1 385/4885
US-20210238161-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM1A, BMI1 GPR3 3139/4885MAPT 2586/4885MEN1 385/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.