Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | MMP14 | P50281 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451418 | 0.83 | MMP7 (0.48) | POLBMMP7CYP3A4MMP13MMP14 | |
| SCHEMBL5883424 | 0.80 | MMP7 (0.53) | POLBMMP7CYP3A4MMP13MMP14 | |
| SCHEMBL7453091 | 0.71 | MMP7 (0.63) | MMP7CYP3A4MMP13MMP14ADAMTS4 | |
| SCHEMBL5883992 | 0.69 | MMP7 (0.79) | POLBMMP7CYP3A4MMP13MMP14 | |
| SCHEMBL6647514 | 0.68 | LMNA (0.40) | POLBTP53KDM4EALDH1A1DRD2 | |
| SCHEMBL21484324 | 0.67 | KDM4E (0.59) | POLBCYP3A4MMP13MMP14ADAMTS4 | |
| SCHEMBL8304525 | 0.66 | CYP3A4 (0.46) | POLBMMP7CYP3A4MMP13MMP14 | |
| SCHEMBL6647886 | 0.66 | MMP7 (0.41) | MMP7CYP3A4MMP13MMP14TP53 | |
| SCHEMBL6786173 | 0.65 | MMP13 (0.46) | POLBCYP3A4MMP13MMP14ADAMTS4 | |
| SCHEMBL5717251 | 0.64 | POLB (0.51) | POLBMAPTKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261590-A1 | PIPERIDINE- AND PIPERAZINE SUBSTITUTED N-HYDROXYFORMAMIDES AS INHIBITORS OF METALLOPROTEINASES | AstraZeneca AB (SE) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062742-A1 | PIPERIDINE- AND PIPERAZINE SUBSTITUTED N-HYDROXYFORMAMIDES AS INHIBITORS OF METALLOPROTEINASES | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |