Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.66 |
| ▸ | THRB | P10828 | 4/20 | 0.66 |
| ▸ | APP | P05067 | 3/20 | 0.65 |
| ▸ | MMP3 | P08254 | 2/20 | 0.65 |
| ▸ | MMP9 | P14780 | 2/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | POLH | Q9Y253 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | FTO | Q9C0B1 | 6/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | TP53 | P04637 | 5/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Robustaflavone SCHEMBL561807 | 0.90 | APP (0.77) | KMT2AMEN1TDP1THRBAPP | |
| Robustaflavone SCHEMBL7643511 | 0.89 | APP (0.76) | KMT2AMEN1TDP1THRBAPP | |
| Robustaflavone SCHEMBL7638211 | 0.89 | APP (0.76) | KMT2AMEN1TDP1THRBAPP | |
| Apigenin SCHEMBL3430874 | 0.87 | CYP3A4 (0.78) | KMT2AMEN1TDP1THRBAPP | |
| Robustaflavone SCHEMBL624405 | 0.85 | APP (0.69) | KMT2AMEN1TDP1THRBAPP | |
| Luteolin SCHEMBL15271260 | 0.84 | POLH (0.75) | KMT2AMEN1TDP1THRBAPP | |
| Luteolin SCHEMBL1229732 | 0.84 | POLH (0.75) | KMT2AMEN1TDP1THRBAPP | |
| Luteolin SCHEMBL30913900 | 0.84 | POLH (0.75) | KMT2AMEN1TDP1THRBAPP | |
| Chrysin SCHEMBL3858957 | 0.84 | ABCB1 (0.84) | KMT2AMEN1TDP1THRBAPP | |
| SCHEMBL17166016 | 0.83 | APP (0.70) | KMT2AMEN1TDP1THRBAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833631-B1 | ROBUSTAFLAVONE AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS | ADVANCED LIFE SCIENCES INC (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-1245230-A2 | Amentoflavone as an antiviral agent | Advanced Life Sciences Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| US-5948918-A | PLANT EXTRACTS | MEDICHEM RESEARCH, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| US-5773462-A | INFLUENZA THERAPY | MEDICHEM RESEARCH, INC. (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0833631-A1 | BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS | MEDICHEM RESEARCH, INC. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000679-A1 | BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS | MEDICHEM RESEARCH, INC. (US) | 1997-01-09 | — | — | WO | disclosed |