Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9433304 | 0.82 | POLB (0.49) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL31716545 | 0.80 | BRD4 (0.58) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL28849019 | 0.80 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL2152756 | 0.79 | BPTF (0.61) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL4105055 | 0.79 | POLB (0.51) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL6271610 | 0.77 | MAPT (0.51) | POLBALDH1A1USP2HPGDMAPT | |
| SCHEMBL5105230 | 0.77 | GRM2 (0.56) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL31021724 | 0.76 | HPGD (0.56) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6265407 | 0.76 | TP53 (0.48) | POLBALDH1A1USP2MAPTTSHR | |
| SCHEMBL14525336 | 0.74 | MTNR1A (0.70) | POLBALDH1A1USP2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891360-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-05-15 | — | — | EP | disclosed |
| US-6001835-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0891360-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036900-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |