Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 9/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 4/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247710 | 0.95 | P2RX7 (0.43) | TPSAB1F2PRSS1F7F3 | |
| SCHEMBL7140320 | 0.82 | F2 (0.47) | TPSAB1F2PRSS1F7F3 | |
| SCHEMBL3242831 | 0.82 | F2 (0.44) | TPSAB1F2PRSS1F7F3 | |
| SCHEMBL3247707 | 0.78 | F2 (0.60) | TPSAB1F2PRSS1F7F3 | |
| SCHEMBL3240576 | 0.78 | MEN1 (0.44) | TP53PLAUMEN1KMT2A | |
| SCHEMBL3266642 | 0.75 | F2 (0.53) | TPSAB1F2PRSS1F7F3 | |
| SCHEMBL5885589 | 0.75 | F2 (0.59) | TPSAB1F2PRSS1F7F3 | |
| SCHEMBL7134782 | 0.74 | P2RX7 (0.47) | TPSAB1F2PRSS1F7F3 | |
| SCHEMBL8205180 | 0.74 | TPSAB1 (0.52) | TPSAB1F2PRSS1F7F3 | |
| SCHEMBL7912621 | 0.74 | TPSAB1 (0.61) | TPSAB1F2PRSS1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0969840-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-02-28 | — | — | EP | disclosed |
| EP-0969840-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998042342-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1998-10-01 | — | — | WO | disclosed |