Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10621833 | 0.83 | KMO (0.57) | KDM4EALDH1A1SMN1; SMN2KMT2AKMO | |
| SCHEMBL7405772 | 0.82 | DYRK1A (0.51) | KDM4EALDH1A1HSD17B10SMN1; SMN2P2RX3 | |
| SCHEMBL7414631 | 0.82 | DYRK1A (0.54) | P2RX3MTNR1AMTNR1BKMO | |
| Iodide SCHEMBL10619045 | 0.82 | KMO (0.56) | KDM4EALDH1A1SMN1; SMN2KMT2AKMO | |
| SCHEMBL10741293 | 0.80 | DYRK1A (0.38) | CTNNB1KDM4EALDH1A1HSD17B10P2RX3 | |
| SCHEMBL9540156 | 0.78 | POLB (0.45) | KDM4EALDH1A1HSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL11681610 | 0.76 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL15478286 | 0.76 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10SMN1; SMN2KMO | |
| SCHEMBL14374704 | 0.75 | CTNNB1 (0.53) | CTNNB1KDM4EALDH1A1SMN1; SMN2CASP3 | |
| SCHEMBL4795814 | 0.75 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10KMT2ACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |