Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414631 | 0.90 | DYRK1A (0.54) | DYRK1AP2RX3MTNR1AMTNR1BPDE3B | |
| SCHEMBL10741293 | 0.83 | DYRK1A (0.38) | DYRK1AP2RX3PDE3BPDE3APDE2A | |
| SCHEMBL7457148 | 0.82 | CTNNB1 (0.47) | P2RX3MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL7408633 | 0.80 | DYRK1A (0.55) | DYRK1AP2RX3KDM4EALDH1A1HPGD | |
| SCHEMBL7412859 | 0.77 | DYRK1A (0.64) | DYRK1AP2RX3KDM4EALDH1A1HPGD | |
| SCHEMBL7414967 | 0.76 | DYRK1A (0.47) | DYRK1AP2RX3MTNR1AMTNR1BKDM4E | |
| SCHEMBL11863365 | 0.75 | GRIN1 (0.50) | PDE3BPDE3A | |
| SCHEMBL19148282 | 0.74 | MTNR1A (0.64) | MTNR1AMTNR1BL3MBTL1ALDH1A1HPGD | |
| SCHEMBL7409652 | 0.74 | DYRK1A (0.54) | DYRK1AP2RX3MTNR1AMTNR1BKDM4E | |
| SCHEMBL11186683 | 0.73 | FPR1 (0.43) | DYRK1AMTNR1AMTNR1BL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |