Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.54 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405772 | 0.90 | DYRK1A (0.51) | DYRK1AP2RX3MTNR1AMTNR1BKMO | |
| SCHEMBL7457148 | 0.82 | CTNNB1 (0.47) | P2RX3MTNR1AMTNR1BKMO | |
| SCHEMBL7412859 | 0.80 | DYRK1A (0.64) | DYRK1AP2RX3KMO | |
| SCHEMBL7408633 | 0.77 | DYRK1A (0.55) | DYRK1AP2RX3 | |
| SCHEMBL10741293 | 0.76 | DYRK1A (0.38) | DYRK1AP2RX3PDE3BPDE3A | |
| SCHEMBL7409652 | 0.76 | DYRK1A (0.54) | DYRK1AP2RX3MTNR1AMTNR1BKMO | |
| SCHEMBL7414967 | 0.74 | DYRK1A (0.47) | DYRK1AP2RX3MTNR1AMTNR1B | |
| SCHEMBL3403616 | 0.72 | MTNR1A (0.46) | DYRK1AMTNR1AMTNR1BKMO | |
| SCHEMBL3409598 | 0.70 | KMO (0.61) | DYRK1AMTNR1AMTNR1BKMO | |
| SCHEMBL7414012 | 0.70 | KMO (0.43) | KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |