SCHEMBL745772

SCHEMBL745772

CC(C)(C)c1ccc(N2CCC3(CCN(S(=O)(=O)c4ccccc4)CC3)C2=O)cc1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LIPE Q05469 1/20 0.53
HSD11B1 P28845 13/20 0.53
MAOA P21397 1/20 0.49
LMNA P02545 1/20 0.49
GAA P10253 1/20 0.49
TSHR P16473 1/20 0.47
TRPV1 Q8NER1 1/20 0.47
MAPT P10636 1/20 0.46
USP2 O75604 1/20 0.46
ALDH1A1 P00352 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22396074 0.84 NEK2 (0.51) LIPETSHRUSP2ALDH1A1CYP1A2
SCHEMBL745437 0.82 LIPE (0.70) LIPETSHR
SCHEMBL744130 0.81 LIPE (0.77) LIPE
SCHEMBL745784 0.81 LIPE (0.53) LIPETSHRUSP2ALDH1A1CYP1A2
SCHEMBL13075173 0.79 LIPE (0.49) LIPETSHRUSP2ALDH1A1CYP1A2
SCHEMBL748276 0.79 LIPE (0.59) LIPE
SCHEMBL746188 0.78 LIPE (0.60) LIPE
SCHEMBL746697 0.78 LIPE (0.50) LIPETSHRUSP2ALDH1A1CYP1A2
SCHEMBL744394 0.77 ALDH1A1 (0.44) LIPETSHRUSP2ALDH1A1CYP1A2
SCHEMBL3753670 0.77 LIPE (0.75) LIPEHSD11B1TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230233484-A1 USE OF VITAMIN K IN PREVENTING OR COUNTERACTING COVID-19 DISEASE AND DIAGNOSTIC TEST TO ESTIMATE THE RISK OF DEVELOPING SEVERE DISEASE OR MORTALITY BY COVID-19 EMPHYSEMA SOLUTIONS BV (NL) 2023-07-27 US claimed
EP-3082865-B1 PREVENTION AND COUNTERACTION OF DIET-INDUCED THROMBOSIS RISK NATTOPHARMA ASA (NO) 2021-08-11 EP claimed
US-20180199610-A1 VITAMIN K AND CAPILLARY FUNCTION VITAK BV (NL) 2018-07-19 US claimed
US-20160310445-A1 PREVENTION AND COUNTERACTION OF DIET-INDUCED THROMBOSIS RISK VITAK B.V. (NL) 2016-10-27 US claimed
EP-3082865-A1 PREVENTION AND COUNTERACTION OF DIET-INDUCED THROMBOSIS RISK VitaK B.V. (NL) 2016-10-26 EP claimed
WO-2015092018-A1 PREVENTION AND COUNTERACTION OF DIET-INDUCED THROMBOSIS RISK VITAK BV (NL) 2015-06-25 WO claimed
EP-2886129-A1 Prevention and counteraction of diet-induced thrombosis risk VitaK B.V. (NL) 2015-06-24 EP claimed
EP-2430023-B1 AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS HOFFMANN LA ROCHE (CH) 2013-12-11 EP claimed
US-20130245598-A1 PHOTOACTIVE VITAMIN NANOPARTICLES FOR THE TREATMENT OF CHRONIC WOUNDS GOVERNORS STATE UNIVERSITY 2013-09-19 US claimed
US-8329904-B2 Azacyclic derivatives HOFFMANN-LA ROCHE INC. (US) 2012-12-11 US claimed
US-20100292212-A1 NEW AZACYCLIC DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2010-11-18 US claimed
US-20090074847-A1 Transport System In Biological Systems BIO TESYS GMBH (DE) 2009-03-19 US claimed
JP-2022241-A None JP disclosed
WO-2024141616-A1 HYDROLYSATE OBTAINED FROM INSECTS AND METHOD FOR PRODUCING SAID HYDROLYSATE YNSECT (FR) 2024-07-04 WO disclosed
CN-114451559-B System and method for preparing powdery fat-soluble micronutrient premix and food 北京金康普食品科技有限公司 2024-06-21 CN disclosed
US-20240189205-A1 ENRICHED TOPICAL COSMETIC COMPOSITION TruSkin Partners, Inc. (US) 2024-06-13 US disclosed
EP-0816490-A2 Mutant prenyl diphosphate synthase TOYOTA JIDOSHA KABUSHIKI KAISHA (JP) 1998-01-07 EP disclosed
EP-0747042-A1 Compositions containing azole derivatives for topical application to skin UNILEVER PLC (GB) 1996-12-11 EP disclosed
CN-1106296-A Nutritional Supplement SANDOZ NUTRITION LTD (CH) 1995-08-09 CN disclosed
JP-H0222241-A FAT-SOLUBLE VITAMIN K-CONTAINING AQUEOUS SOLUTION EISAI CO LTD 1990-01-25 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160310445-A1 PREVENTION AND COUNTERACTION OF DIET-INDUCED THROMBOSIS RISK PROC, F10, MAPK10 LIPE 2211/4885HSD11B1 2453/4885MAOA 4617/4885
US-20100292212-A1 NEW AZACYCLIC DERIVATIVES GPR119, LDLR, LPL LIPE 10/4885HSD11B1 189/4885MAOA 1517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.