Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 11/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.51 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.51 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 11/20 | 0.50 |
| ▸ | MMP13 | P45452 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559727 | 0.98 | MMP9 (0.82) | MMP9LMNANR3C1PGRALDH1A1 | |
| SCHEMBL8577457 | 0.92 | MMP9 (0.76) | MMP9LMNANR3C1PGRALDH1A1 | |
| SCHEMBL7463817 | 0.88 | MMP9 (1.00) | MMP9MMP1MMP13ADAM17 | |
| SCHEMBL6559584 | 0.87 | MMP9 (0.75) | MMP9LMNANR3C1PGRALDH1A1 | |
| SCHEMBL7457791 | 0.82 | MMP9 (0.75) | MMP9LMNAMMP1MMP13MAPT | |
| SCHEMBL7453335 | 0.78 | MMP9 (0.68) | MMP9LMNANR3C1PGRALDH1A1 | |
| Hydroxyamine SCHEMBL8521994 | 0.77 | MMP9 (0.58) | MMP9LMNANR3C1PGRALDH1A1 | |
| SCHEMBL27569110 | 0.76 | MMP13 (0.70) | MMP9LMNANR3C1PGRALDH1A1 | |
| SCHEMBL7321133 | 0.76 | MMP13 (0.66) | MMP9LMNANR3C1PGRALDH1A1 | |
| SCHEMBL6289428 | 0.75 | MMP1 (0.72) | MMP9MMP1MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934300-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016520-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |