Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456380 | 0.86 | CHRM1 (0.44) | CHRM1MEN1KMT2ACHRM2CHRM5 | |
| SCHEMBL8783358 | 0.82 | CHRM1 (0.43) | CHRM1MEN1KMT2ACHRM2CHRM5 | |
| SCHEMBL8783362 | 0.82 | CHRM1 (0.43) | CHRM1MEN1KMT2ACHRM2CHRM5 | |
| SCHEMBL8783996 | 0.81 | CYP2C19 (0.56) | CHRM1MEN1KMT2ACHRM2CHRM5 | |
| SCHEMBL8784000 | 0.81 | CYP2C19 (0.56) | CHRM1MEN1KMT2ACHRM2CHRM5 | |
| SCHEMBL7457776 | 0.78 | CYP2D6 (0.44) | CHRM1MEN1KMT2ANFKB1KDM4E | |
| SCHEMBL8655841 | 0.77 | HTR1A (0.52) | CHRM1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL7108946 | 0.73 | CHRM1 (0.40) | CHRM1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL7453757 | 0.73 | HTR1A (0.58) | KDM4EPOLBALDH1A1 | |
| SCHEMBL909284 | 0.71 | CYP2C19 (0.53) | MEN1KMT2ALMNAPOLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782574-B1 | BICYCLIC CARBOXAMIDES AS 5-HT1A RECEPTORS LIGANDS | WYETH JOHN & BROTHER LTD (GB) | 2002-03-27 | — | — | EP | disclosed |
| EP-0782574-A1 | BICYCLIC CARBOXAMIDES AS 5-HT 1A? ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| US-5610154-A | ANXIOLYTIC AGENTS | JOHN WYETH & BROTHER, LTD. (GB) | 1997-03-11 | — | — | US | disclosed |
| WO-1996009302-A1 | BICYCLIC CARBOXAMIDES AS 5-HT1A ANTAGONISTS | JOHN WYETH & BROTHER LTD. (GB) | 1996-03-28 | — | — | WO | disclosed |