Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457776 | 0.82 | CYP2D6 (0.44) | CHRM1ALDH1A1GAAKDM4ELMNA | |
| SCHEMBL8655841 | 0.78 | HTR1A (0.52) | CHRM1ALDH1A1TSHRGAAKDM4E | |
| SCHEMBL7458164 | 0.73 | CHRM1 (0.44) | CHRM1ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL909284 | 0.72 | CYP2C19 (0.53) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL7830236 | 0.72 | CYP2C19 (0.53) | ALDH1A1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL11637533 | 0.72 | CYP2C19 (0.44) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL8654674 | 0.72 | CYP2C19 (0.36) | CHRM1ALDH1A1TSHRGAALMNA | |
| SCHEMBL7037673 | 0.71 | CHRM1 (0.45) | CHRM1ALDH1A1KDM4E | |
| SCHEMBL7460894 | 0.71 | HTR1A (0.75) | ALDH1A1KDM4ELMNAKMT2A | |
| Hydrochloric Acid SCHEMBL908468 | 0.71 | CYP2C19 (0.52) | ALDH1A1LMNAMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782574-B1 | BICYCLIC CARBOXAMIDES AS 5-HT1A RECEPTORS LIGANDS | WYETH JOHN & BROTHER LTD (GB) | 2002-03-27 | — | — | EP | claimed |
| EP-1037637-B1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | UNIV PRINCETON (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-0782574-B1 | BICYCLIC CARBOXAMIDES AS 5-HT1A RECEPTORS LIGANDS | WYETH JOHN & BROTHER LTD (GB) | 2002-03-27 | — | — | EP | disclosed |
| US-5919802-A | Methods of preventing and/or treating temporal lobe epilepsy | PRINCETON UNIVERSITY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5610154-A | ANXIOLYTIC AGENTS | JOHN WYETH & BROTHER, LTD. (GB) | 1997-03-11 | — | — | US | disclosed |