Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | PNMT | P11086 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103625 | 0.82 | GAA (0.46) | GAALMNAL3MBTL1GFERSMN1; SMN2 | |
| SCHEMBL103624 | 0.82 | GAA (0.46) | GAALMNAL3MBTL1GFERSMN1; SMN2 | |
| SCHEMBL13770580 | 0.79 | GAA (0.43) | GAALMNAL3MBTL1GFERSMN1; SMN2 | |
| SCHEMBL21163691 | 0.77 | LMNA (0.44) | GAALMNAL3MBTL1GFERSMN1; SMN2 | |
| SCHEMBL871585 | 0.77 | BCAT2 (0.51) | GAALMNAL3MBTL1MAPTKDM1A | |
| SCHEMBL19153981 | 0.77 | BCAT2 (0.51) | GAALMNAL3MBTL1MAPTKDM1A | |
| Water SCHEMBL871348 | 0.76 | BCAT2 (0.50) | GAALMNAL3MBTL1MAPTKDM1A | |
| SCHEMBL3188911 | 0.74 | PNMT (0.43) | LMNAPNMTSMN1; SMN2HTTDPP4 | |
| SCHEMBL405123 | 0.74 | KDM4E (0.52) | GAAL3MBTL1PNMTMAPTHTT | |
| SCHEMBL29674786 | 0.74 | PNMT (0.43) | LMNAPNMTSMN1; SMN2HTTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016201052-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2016-12-15 | — | — | WO | disclosed |
| EP-0669317-B1 | Prolineamide derivatives | MITSUBISHI CHEM CORP (JP) | 2002-09-04 | — | — | EP | disclosed |
| US-5744487-A | PROTEASE INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-04-28 | — | — | US | disclosed |
| EP-0669317-A1 | Prolineamide derivatives | Mitsubishi Chemical Corporation (JP) | 1995-08-30 | — | — | EP | disclosed |