Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2900931 | 0.84 | ALDH1A1 (0.50) | SLC6A2SLC6A3TSHRALDH1A1 | |
| SCHEMBL8316188 | 0.83 | CHRNB2 (0.46) | NMT1TSHRCHRM3HTR2CALDH1A1 | |
| SCHEMBL2854195 | 0.82 | CYP2C19 (0.49) | SLC6A2SLC6A3TSHRALDH1A1 | |
| SCHEMBL3922320 | 0.79 | NMT1 (0.50) | NMT1HRH1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL13402324 | 0.79 | SCN1A (0.57) | HRH1SLC6A3CHRM3HTR2CALDH1A1 | |
| SCHEMBL6535407 | 0.79 | TSHR (0.47) | NMT1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8908923 | 0.78 | CYP19A1 (0.53) | HRH1CHRM3ALDH1A1 | |
| SCHEMBL606466 | 0.78 | TSHR (0.55) | NMT1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15028224 | 0.78 | NMT1 (0.57) | NMT1HRH1ALDH1A1 | |
| SCHEMBL30089914 | 0.78 | CYP1A2 (0.51) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697408-B1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 2002-01-23 | — | — | EP | disclosed |
| EP-0623615-B1 | Substituted 1-phenyl-oxazolidin-2-one derivatives, their preparation and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 1999-06-30 | — | — | EP | disclosed |
| WO-1996020173-A1 | PIPERAZINE DERIVATIVES, MEDICAMENTS CONTAINING THE SAME, THEIR USE AND PROCESS FOR PREPARING THE SAME | DR. KARL THOMAE GMBH (DE) | 1996-07-04 | — | — | WO | disclosed |
| EP-0697408-A1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1996-02-21 | — | — | EP | disclosed |
| EP-0623615-A1 | Adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1994-11-09 | — | — | EP | disclosed |