Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ4 | P56696 | 3/20 | 0.37 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464517 | 0.89 | ACHE (0.36) | CYP17A1LMNASREBF2HDAC3HDAC1 | |
| SCHEMBL7468376 | 0.83 | KCNQ4 (0.40) | KCNQ4KCNQ5CYP17A1WNT3AHDAC3 | |
| SCHEMBL5869009 | 0.80 | TLR9 (0.39) | KCNQ4KCNQ5CYP17A1LMNATDP1 | |
| SCHEMBL7464951 | 0.78 | ACHE (0.41) | LMNATDP1HDAC3HDAC1HDAC2 | |
| SCHEMBL5868977 | 0.77 | CYP17A1 (0.39) | KCNQ4KCNQ5CYP17A1LMNATDP1 | |
| SCHEMBL7707033 | 0.75 | HPGDS (0.38) | HDAC3HDAC1RAB9AHDAC6 | |
| SCHEMBL7459594 | 0.74 | KCNQ4 (0.40) | KCNQ4KCNQ5CYP17A1HDAC3HDAC1 | |
| SCHEMBL5868756 | 0.73 | KCNQ4 (0.44) | KCNQ4KCNQ5CYP17A1LMNATDP1 | |
| SCHEMBL5869167 | 0.72 | HDAC6 (0.41) | KCNQ4KCNQ5CYP17A1HDAC3HDAC1 | |
| SCHEMBL5557524 | 0.71 | CYP17A1 (0.50) | KCNQ4KCNQ5CYP17A1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224175-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |