Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460091 | 0.81 | HPGDS (0.38) | HPGDSHDAC3HDAC1HDAC6ABCB1 | |
| SCHEMBL7465633 | 0.75 | MAPT (0.55) | RAB9ANPC1POLBHPGDMAPT | |
| SCHEMBL7459709 | 0.75 | KCNQ4 (0.37) | HDAC3HDAC1HDAC6RAB9A | |
| SCHEMBL7464517 | 0.73 | ACHE (0.36) | HPGDSHDAC3HDAC1HDAC6ACHE | |
| SCHEMBL7466309 | 0.72 | ERCC5 (0.36) | HDAC3HDAC1MAPT | |
| SCHEMBL5869050 | 0.71 | ALDH1A1 (0.36) | HPGDSPOLBABCB1HPGDMAPT | |
| SCHEMBL5161432 | 0.66 | L3MBTL1 (0.38) | MAPTALDH1A1GAA | |
| SCHEMBL5868797 | 0.65 | CHEK1 (0.44) | RAB9APOLBABCB1HPGDMAPT | |
| SCHEMBL14753396 | 0.65 | ALDH1A1 (0.35) | MAPTALDH1A1 | |
| SCHEMBL3821418 | 0.63 | MAPT (0.46) | RAB9ANPC1POLBHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |