Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | BRS3 | P32247 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | ERG | P11308 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7845666 | 0.99 | CHRM4 (0.53) | CHRM4KDM4ECHRM2GPBAR1CHRM1 | |
| SCHEMBL7459728 | 0.82 | FNTA (0.42) | GPBAR1BRS3EP300ERG | |
| Hydrochloric Acid SCHEMBL7452346 | 0.82 | FNTA (0.42) | GPBAR1BRS3EP300ERG | |
| Hydrochloric Acid SCHEMBL7830292 | 0.81 | CHRM4 (0.42) | CHRM4BRS3EP300 | |
| SCHEMBL7921304 | 0.75 | BRS3 (0.52) | CHRM4BRS3EP300 | |
| SCHEMBL8413422 | 0.74 | BRS3 (0.47) | KDM4EBRS3 | |
| SCHEMBL15808499 | 0.73 | KDM4E (0.73) | CHRM4KDM4ECHRM2 | |
| SCHEMBL7464954 | 0.72 | FNTA (0.45) | BRS3 | |
| SCHEMBL7682555 | 0.72 | ACKR3 (0.40) | GPBAR1BRS3EP300ERG | |
| SCHEMBL8300491 | 0.71 | FNTA (0.41) | BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |